Kompleks Oksovanadium (IV) Sebagai Insulin-Mimetik
DOI:
https://doi.org/10.32493/jiptek.v5i1.35234Keywords:
Diabetes Melitus, Vanadium, KoordinasiAbstract
Diabetes Melitus (DM) merupakan penyakit yang banyak diderita oleh masyarakat di dunia diklasifikasikan sebagai diabetes tipe 1 dan 2. Berbagai pengembangan dilakukan untuk menurunkan kadar gula darah penderita diabetes. Pada abad ke 21, penelitian mengenai metalofarmatikal banyak dikembangkan dengan menggunakan logam vanadium sebagai anti-diabetes. Pada artikel ini, perkembangan kompleks vanadium sebagai insulin mimetik dengan berbagai macam koordinasi direview berdasarkan hasil uji secara in vivo dan in vitroReferences
IDF, “IDF Diabetes Atlas 2021: 10th Edition,†Brussels, 2021.
A. Stern, X. Yin, S.-S. Tsang, A. Davison, and J. Moon, “Vanadium as a modulator of cellular regulatory cascades and oncogene expression,†Biochem. cell Biol., vol. 71, no. 3–4, pp. 103–112, 1993, doi: https://doi.org/10.1139/o93-018.
N. Cohen, M. Halberstam, P. Shlimovich, C. J. Chang, H. Shamoon, and L. Rossetti, “Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus.,†J. Clin. Invest., vol. 95, no. 6, pp. 2501–2509, 1995, doi: https://doi.org/10.1172/JCI117951.
A. B. Goldfine, D. C. Simonson, F. Folli, M. E. Patti, and C. R. Kahn, “Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies,†J. Clin. Endocrinol. Metab., vol. 80, no. 11, pp. 3311–3320, Nov. 1995, doi: 10.1210/jcem.80.11.7593444.
A. B. Goldfine, D. C. Simonson, F. Folli, M.-E. Patti, and C. R. Kahn, “In vivo andin vitro studies of vanadate in human and rodent diabetes mellitus,†Mol. Cell. Biochem., vol. 153, no. 1, pp. 217–231, 1995, doi: 10.1007/BF01075941.
M. Halberstam, N. Cohen, P. Shlimovich, L. Rossetti, and H. Shamoon, “Oral Vanadyl Sulfate Improves Insulin Sensitivity in NIDDM but Not in Obese Nondiabetic Subjects,†Diabetes, vol. 45, no. 5, pp. 659–666, May 1996, doi: 10.2337/diab.45.5.659.
G. Boden, X. Chen, J. Ruiz, G. D. V van Rossum, and S. Turco, “Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non—insulin-dependent diabetes mellitus,†Metabolism, vol. 45, no. 9, pp. 1130–1135, 1996, doi: https://doi.org/10.1016/S0026-0495(96)90013-X.
A. B. Goldfine et al., “Metabolic effects of vanadyl sulfate in humans with non—insulin-dependent diabetes mellitus: In vivo and in vitro studies,†Metabolism, vol. 49, no. 3, pp. 400–410, 2000, doi: https://doi.org/10.1016/S0026-0495(00)90418-9.
H. Sakurai et al., “Insulin-Mimetic Action of Vanadyl Complexes,†J. Clin. Biochem. Nutr., vol. 8, no. 3, pp. 193–200, 1990, doi: 10.3164/jcbn.8.193.
H. Sakurai, Y. Fujisawa, S. Fujimoto, H. Yasui, and T. Takino, “Role of vanadium in treating diabetes,†J. Trace Elem. Exp. Med., vol. 12, no. 4, pp. 393–401, Jan. 1999, doi: https://doi.org/10.1002/(SICI)1520-670X(1999)12:4<393::AID-JTRA13>3.0.CO;2-P.
H. Sakurai, K. Tsuchiya, M. Nukatsuka, M. Sofue, and J. Kawada, “Insulin-like effect of vanadyl ion on streptozotocin-induced diabetic rats,†J. Endocrinol., vol. 126, no. 3, pp. 451–459, 1990, doi: 10.1677/joe.0.1260451.
R. G. Pearson, “Hard and Soft Acids and Bases,†J. Am. Chem. Soc., vol. 85, no. 22, pp. 3533–3539, Nov. 1963, doi: 10.1021/ja00905a001.
H. Sakurai, Y. Hamada, S. Shimomura, and S. Yamashita, “Cysteine Methyl Ester-Oxovanadium(IV) Complex, Preparation and Characterization,†Inorganica Chim. Acta, vol. 46, pp. L119–L120, 1980, doi: https://doi.org/10.1016/S0020-1693(00)84158-4.
H. Watanabe, M. Nakai, K. Komazawa, and H. Sakurai, “A new orally active insulin-mimetic vanadyl complex: bis(pyrrolidine-N-carbodithioato)oxovanadium(IV),†J. Med. Chem., vol. 37, no. 7, pp. 876–877, Apr. 1994, doi: 10.1021/jm00033a002.
H. Sakurai, H. Watanabe, H. Tamura, H. Yasui, R. Matsushita, and J. Takada, “Insulin-mimetic vanadyl—dithiocarbamate complexes,†Inorganica Chim. Acta, vol. 283, no. 1, pp. 175–183, 1998, doi: https://doi.org/10.1016/S0020-1693(98)00309-0.
H. Sakurai, H. Sano, T. Takino, and H. Yasui, “A New Type of Orally Active Insulin-Mimetic Vanadyl Complex: Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) with VO(S2O2) Coordination Mode,†Chem. Lett., vol. 28, no. 9, pp. 913–914, Sep. 1999, doi: 10.1246/cl.1999.913.
H. Sakurai, H. Sano, T. Takino, and H. Yasui, “An orally active antidiabetic vanadyl complex, bis(1-oxy-2-pyridinethiolato)oxovanadium(IV), with VO(S2O2) coordination mode; in vitro and in vivo evaluations in rats,†J. Inorg. Biochem., vol. 80, no. 1, pp. 99–105, 2000, doi: https://doi.org/10.1016/S0162-0134(00)00045-3.
H. Sakurai, K. Fujii, H. Watanabe, and H. Tamura, “Orally Active and Long-Term Acting Insulin-Mimetic Vanadyl Complex: Bis(Picolinato)oxovanadium(IV),†Biochem. Biophys. Res. Commun., vol. 214, no. 3, pp. 1095–1101, 1995, doi: https://doi.org/10.1006/bbrc.1995.2398.
S. Fujimoto, K. Fujii, H. Yasui, R. Matsushita, J. Takada, and H. Sakurai, “Long-Term Acting and Orally Active Vanadyl-Methylpicolinate Complex with Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats,†J. Clin. Biochem. Nutr., vol. 23, no. 2, pp. 113–129, 1997, doi: https://doi.org/10.3164/jcbn.23.113.
R. Tawa et al., “A New Insulin-mimetic Vanadyl Complex, (N-Pyridylmethylaspartate)oxovanadium(IV) with VO(N2O2) Coordination Mode, and Evaluation of its Effect on Uptake of D-Glucose by Ehrlich Ascites Tumour Cells,†J. Pharm. Pharmacol., vol. 51, no. 2, pp. 119–124, Feb. 1999, doi: https://doi.org/10.1211/0022357991772213.
H. Sakurai, “Interaction of vanadyl complexes with biological systems : structure-insulinomimetic activity relationship of vanadyl-picolinate complexes,†Inorg Reac Mecha, vol. 2, pp. 69–77, 2000, Accessed: Nov. 03, 2023. [Online]. Available: https://cir.nii.ac.jp/crid/1571135650836861696.bib?lang=ja.
T. Takino et al., “A new halogenated antidiabetic vanadyl complex, bis(5-iodopicolinato)oxovanadium(IV): in vitro and in vivo insulinomimetic evaluations and metallokinetic analysis,†JBIC J. Biol. Inorg. Chem., vol. 6, no. 2, pp. 133–142, 2001, doi: 10.1007/s007750000182.
J. H. McNeill, V. G. Yuen, H. R. Hoveyda, and C. Orvig, “Bis(maltolato)oxovanadium(IV) is a potent insulin mimic,†J. Med. Chem., vol. 35, no. 8, pp. 1489–1491, Apr. 1992, doi: 10.1021/jm00086a020.
V. G. Yuen, C. Orvig, K. H. Thompson, and J. H. McNeill, “Improvement in cardiac dysfunction in streptozotocin-induced diabetic rats following chronic oral administration of bis(maltolato)oxovanadium(IV),†Can. J. Physiol. Pharmacol., vol. 71, no. 3–4, pp. 270–276, Mar. 1993, doi: 10.1139/y93-042.
S. A. Dikanov et al., “In vivo electron spin-echo envelope modulation (ESEEM) spectroscopy: First observation of vanadyl coordination to phosphate in bone,†J. Am. Chem. Soc., vol. 121, no. 47, pp. 11004–11005, 1999, doi: https://doi.org/10.1021/ja991567m.
K. Kawabe, M. Tadokoro, Y. Kojima, Y. Fujisawa, and H. Sakurai, “Syntheses, Structures, and Insulin-like Activities of Two Vanadyl Complexes; [VO(GeG)(H2O)] and [VO(MeM)(H2O)],†Chem. Lett., vol. 27, no. 1, pp. 9–10, Jan. 1998, doi: 10.1246/cl.1998.9.
K. Kawabe, M. Tadokoro, A. Ichimura, Y. Kojima, T. Takino, and H. Sakurai, “Stereospecific and Structure-Dependent Insulin-Mimetic Oxovanadium(IV) Complexes with N,N‘-Ethylenebis(amino acids),†J. Am. Chem. Soc., vol. 121, no. 34, pp. 7937–7938, Sep. 1999, doi: 10.1021/ja984225+.
K. Kawabe et al., “Syntheses, Structures, and Insulin-like Activities of Oxovanadium(IV) Complexes with Tetra- and Penta-dentate Histidine Derivatives,†Chem. Lett., vol. 27, no. 11, pp. 1155–1156, Nov. 1998, doi: 10.1246/cl.1998.1155.
S. Tamura, T. A. Brown, R. E. Dubler, and J. Larner, “Insulin-like effect of vanadate on adipocyte glycogen synthase and on phosphorylation of 95,000 dalton subunit of insulin receptor,†Biochem. Biophys. Res. Commun., vol. 113, no. 1, pp. 80–86, 1983, doi: https://doi.org/10.1016/0006-291X(83)90434-5.
S. Tamura et al., “A novel mechanism for the insulin-like effect of vanadate on glycogen synthase in rat adipocytes.,†J. Biol. Chem., vol. 259, no. 10, pp. 6650–6658, 1984, doi: https://doi.org/10.1016/S0021-9258(20)82192-9.
M. Bernier, D. M. Laird, and M. D. Lane, “Effect of vanadate on the cellular accumulation of pp15, an apparent product of insulin receptor tyrosine kinase action.,†J. Biol. Chem., vol. 263, no. 27, pp. 13626–13634, Sep. 1988, doi: 10.1016/S0021-9258(18)68288-2.
R. Gherzi et al., “Direct modulation of insulin receptor protein tyrosine kinase by vanadate and anti-insulin receptor monoclonal antibodies,†Biochem. Biophys. Res. Commun., vol. 152, no. 3, pp. 1474–1480, 1988, doi: https://doi.org/10.1016/S0006-291X(88)80452-2.
A. Ueno, N. Arakaki, Y. Takeda, and H. Fujio, “Inhibition of tyrosine autophosphorylation of the solubilized insulin receptor by an insulin-stimulating peptide derived from bovine serum albumin,†Biochem. Biophys. Res. Commun., vol. 144, no. 1, pp. 11–18, 1987, doi: https://doi.org/10.1016/S0006-291X(87)80468-0.
D. M. Smith and G. J. Sale, “Evidence that a novel serine kinase catalyses phosphorylation of the insulin receptor in an insulin-dependent and tyrosine kinase-dependent manner,†Biochem. J., vol. 256, no. 3, pp. 903–909, Dec. 1988, doi: 10.1042/bj2560903.
G. R. Dubyak and A. Kleinzeller, “The insulin-mimetic effects of vanadate in isolated rat adipocytes. Dissociation from effects of vanadate as a (Na+-K+) ATPase inhibitor.,†J. Biol. Chem., vol. 255, no. 11, pp. 5306–5312, 1980.
N. Okumura and T. Shimazu, “Vanadate Stimulates D-Glucose Transport into Sarcolemmal Vesicles from Rat Skeletal Muscles1,†J. Biochem., vol. 112, no. 1, pp. 107–111, Jul. 1992, doi: 10.1093/oxfordjournals.jbchem.a123846.
M. R. Pâquet, R. J. Romanek, and R. J. Sargeant, “Vanadate induces the recruitment of glut-4 glucose transporter to the plasma membrane of rat adipocytes,†Mol. Cell. Biochem., vol. 109, no. 2, pp. 149–155, 1992, doi: 10.1007/BF00229769.
D. W. Boyd and K. Kustin, “Vanadium: a versatile biochemical effector with an elusive biological function,†Adv. Inorg. Biochem., vol. 6, pp. 311–365, 1984, [Online]. Available: http://europepmc.org/abstract/MED/6152574.
E. Erdmann, K. Werdan, W. Krawietz, W. Schmitz, and H. Scholz, “Vanadate and its significance in biochemistry and pharmacology,†Biochem. Pharmacol., vol. 33, no. 7, pp. 945–950, 1984.
T. Ramasarma and F. L. Crane, “Does Vanadium Play a Role in Cellular Regulation?,†Curr. Top. Cell. Regul., vol. 20, pp. 247–301, 1981, doi: https://doi.org/10.1016/B978-0-12-152820-1.50011-0.
